Preprint: H.E. Greenwood, R.S. Edwards, W.E. Tyrrell, A.R. Barber, F. Baark, M. Tanc, E. Khalil, A. Falzone, N.P. Ward, J.M. DeBlasi, L. Torrente, D.R. Pearce, G. Firth, L.M. Smith, O. Vilhelmsson Timmermand, A. Huebner, M.E. George, C. Swanton, R.E. Hynds, G.M. DeNicola, T.H. Witney (2023). Imaging the master regulator of the antioxidant response in non-small cell lung cancer with positron emission tomography. bioRxiv. DOI: 10.1101/2023.12.16.572007

T.H. Witney (2024). Introducing npj Imaging: a new journal to serve the bio- and medical imaging communities. npj Imaging 2, 10.

A.R. Sharkey, N. Koglin, E.S. Mittra, S. Han, G.J.R. Cook† & T.H. Witney† (2024). Clinical [18F]FSPG PET/CT imaging reveals heterogeneity in tumor-associated system xc− activity. Cancers 16, 1437.

Y. Song, J. Zou, E.A Castellanos, N. Matsuura, J.A. Ronald, A.J. Shuhendler, W.A Weber†, A.A. Gilad†, C. Müller†, T.H. Witney† & X. Chen† (2024). Theranostics – a sure cure for cancer after 100 years? Theranostics 14, pp.2464-2488.

K. Sambasivan, S. Barrington, S. Connor, T.H. Witney, P. Blower & T. Guerrero Urbano (2024). Is there a role for [18F]FMISO PET to guide dose adaptive radiotherapy in head and neck cancer? A review of the literature. Clin Transl Imaging 12, pp.137-155.

S. Gurung, O.V. Timmermand, D. Perocheau, A. Luisa Gil-Martinez, M. Minnion, L. Touramanidou, S. Fang, M. Messina, Y. Khalil, A.R. Barber, R.S. Edwards, P.F. Finn, A. Cavedon, S. Siddiqui, L. Rice, P.G.V. Martini, P.B. Mills, S.N. Waddington, P. Gissen, S. Eaton, M. Ryten, M. Feelisch, A. Frassetto, T.H. Witney† & Julien Baruteau† (2024). mRNA therapy restores ureagenesis and corrects glutathione metabolism in argininosuccinic aciduria. Sci Transl Med 16, eadh1334.

A.R. Sharkey, T.H. Witney† & G. Cook† (2023). Is system xc- a suitable target for tumour detection and response? Cancers 15, 5573.

L.M. Smith, H.E Greenwood, W.E. Tyrrell, R.S. Edwards, V. de Santis, F. Baark, G. Firth, M. Tanc, S.Y.A. Terry, A. Herrmann, R. Southworth† & T.H Witney† (2023). The Chicken Chorioallantoic Membrane as a Low-Cost, High-Throughput Model for Cancer Imaging. npj Imaging 1, 1.

T.H. Witney & A.J. Shuhendler (2023). Positron Emission Tomography: Methods and Protocols, vol 2729. Humana Press, New York, NY.

O. Vilhelmsson Timmermand & T.H. Witney (2023). Imaging the Tumor Antioxidant Response with [18F]FSPG PET. In: Haznadar M. (eds) Positron Emission Tomography: Methods and Protocols, vol 2729. Humana Press, New York, NY.

R. Pereira*, R.L. Flaherty*, R. Edwards*, H.E. Greenwood, A.J. Shuhendler & T.H. Witney (2022). A Prodrug Strategy for the In Vivo Imaging of Aldehyde Dehydrogenase Activity. RSC Chem Bio 3, pp.561-570.

H.E. Greenwood*, R. Edwards*, N. Koglin, M. Berndt, F. Baark, J. Kim, G. Firth, E. Khalil, A. Mueller & T.H. Witney (2022). Radiotracer stereochemistry affects substrate affinity and kinetics for improved imaging of system xC- in tumors. Theranostics 12, pp.1921-1936.

H.E. Greenwood & T.H. Witney (2021). Latest advances in imaging oxidative stress in cancer. J Nucl Med 62, pp.1506-1510.

R. Edwards, H.E. Greenwood, G. McRobbie, I. Khan & T.H. Witney (2021). Robust and Facile Automated Radiosynthesis of [18F]FSPG on the GE FASTlab. Mol Imaging Biol. DOI:10.1007/s11307-021-01609-w.

T.H. Witney & P.J. Blower (2021). The chemical tool-kit for molecular imaging with radionuclides in the age of targeted and immune therapy. Cancer Imaging 21, 18.

H.E. Greenwood, Z.Nyitrai, G. Mocsai, S. Hobor and T.H. Witney (2020). High Throughput PET/CT Imaging Using a Multiple Mouse Imaging System. J Nucl Med 62, pp.292-297.

T. Gendron*, R. Pereira*, H.Y. Abdi, T.H. Witney† & E. Årstad† (2020). A Practical Iron-based Newman-Kwart Rearrangement Under Oxidative Conditions. Org Lett 22, pp.274-278.

M. Glaser, V. Rajkumar , S. Diocou, Dr. T. Gendron, R. Yan, B.P.K. Sin, K. Sander, L. Carroll, R.B Pedley, E. Aboagye, T.H. Witney and Erik Årstad (2019). One-Pot Radiosynthesis and Biological Evaluation of a Caspase-3 Selective 5-[123,125I]iodo-1,2,3-triazole derived Isatin SPECT Tracer. Sci Rep 9, 19299.

H.E. Greenwood*, R. Edwards*, T.H. Witney (2019). A beginner's guide to imaging in vivo tumour biochemistry. The Biochemist 41, pp.42-27.

M. Krekorian, G.O. Fruhwirth, M. Srinivas, C.G. Figdor, S. Heskamp, T.H. Witney, E.H.J.G. Aarntzen (2019). Imaging of T-cells and their responses during anti-cancer immunotherapy. Theranostics 9, pp.7924-7947.

R. Kimura, L. Wang , B. Shen, L. Huo, W. Tummers, F. Filipp, H. Guo, T. Haywood, L. Abou-Elkacem, L Baratto, F Habte, R. Devulapally, T.H. Witney, Y. Cheng, S. Tikole, S. Chakraborti, J. Nix , C. Bonagura, N. Hatami, J. Mooney, T. Desai, S. Turner, R. Gaster, A. Otte, B. Visser, G. Poultsides, J. Norton, W. Park, M. Stolowitz, K. Lau, E. Yang, A. Natarajan, O. Ilovich, S. Srinivas, A. Srinivasan, R. Paulmurugan, J. Willmann, F. Chin, Z. Cheng, A. Iagaru, F. Li and S.S. Gambhir (2019). Evaluation of Integrin αvβ6 Cystine Knot PET Tracers to Detect Cancer and Idiopathic Pulmonary Fibrosis. Nat Commun. 10, 4673.

A.J. Shuhendler, L. Cui, Z. Chen, B. Shen, M.L. James, T.H. Witney, S.S. Gambhir, F.T. Chin, M. Bazalova-Carter, E. Graves, J. Rao and M. Chen (2019). [18F]-SuPAR: A radiofluorinated probe for non-invasive imaging of DNA damage-dependent Poly (ADP-ribose) Polymerase Activity. Bioconjugate Chem 30, pp.1331-1342.

T.H. Witney and D.Y. Lewis (2019). Imaging Cancer Metabolism with Positron Emission Tomography (PET). In: Haznadar M. (eds) Cancer Metabolism. Methods in Molecular Biology, vol 1928. Humana Press, New York, NY.

H.E. Greenwood, P.N. McCormick, T. Gendron, M. Glaser, R. Pereira, O.D.K Maddocks, K. Sander, T. Zhang, N. Koglin, M.F. Lythgoe, E. Årstad, D. Hochhauser and T.H. Witney (2019). Measurement of tumor antioxidant capacity and prediction of chemotherapy resistance in preclinical models of ovarian cancer by positron emission tomography. Clin Cancer Res 25, pp.2471-2482.

R. Pereira, T. Genderon, C. Sanghera, H.E. Greenwood, J. Newcombe, P.N. McCormick, K. Sander, M. Topf, E. Årstad, T.H. Witney (2019). Mapping aldehyde dehydrogenase 1A1 activity using an [18F]substrate-based approach. Chem Eur J 25, pp.2345-51.

P.N. McCormick, H.E. Greenwood, M. Glaser, O.D.K. Maddocks, T. Gendron, K. Sander, G. Gowrishankar, A. Hoehne, T. Zhang, A.J. Shuhendler, D.Y. Lewis, M. Berndt, N. Koglin, M.F. Lythgoe, S.S. Gambhir, E. Årstad and T.H. Witney (2019). Assessment of tumor redox status through (S)-4-(3-[18F]fluoropropyl)-L-glutamic acid positron emission tomography imaging of system xc- activity. Cancer Res 79, pp.853-63

A. Hoehne*, M.L. James*, I.S. Alam, J.A. Ronald, B. Schneider, A. D’Souza, T.H. Witney, L.E. Andrews, H.C. Cropper, D. Behera, G. Gowrishankar, Z. Ding, T. Wyss-Coray, F.T. Chin, S. Biswal and S.S. Gambhir (2018). [18F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis. J Neuroinflammation 15:55.          

S. Schelhaas, K. Heinzmann, D.J. Honess, D-M Smith, H. Keen, S. Heskamp, T.H. Witney, L. Besret, S. Doblas, J.R. Griffiths, E.O. Aboagye, A.H. Jacobs (2017). 3′-Deoxy-3′-[18F]Fluorothymidine Uptake Is Related to Thymidine Phosphorylase Expression in Various Experimental Tumor Models. Mol Imaging Biol 20, pp.194-9.

A.A. Neves, B. Xie, S. Fawcett, I.S. Alam, T.H. Witney, M.M. de Backer, J. Summers, W. Hughes, S. McGuire, D. Soloviev, J Miller, William J. Howat, D-E Hu, T.B. Rodrigues, D.Y. Lewis, K.M. Brindle (2017). Rapid Imaging of Tumor Cell Death in vivo using the C2A domain of Synaptotagmin-I. J Nucl Med 58, pp.881-7.

K.V. Keu*, T.H. Witney*, S. Yaghoubi*, J. Rosenberg, A. Kurien, R. Magnusson, J. Williams, F. Habte, J.R. Wagner, S. Forman, C. Brown, M. Allen-Auerbach, J. Czernin, W. Tang, M.C. Jensen, B. Badie, S.S. Gambhir (2017). Reporter Gene Imaging of Targeted T-Cell Immunotherapy in Recurrent Glioma. Sci Transl Med 9, eeag2196.

K. Heinzmann, D.J. Honess, D.Y. Lewis, D-M Smith, C. Cawthorne, H. Keen, S. Heskamp, S. Schelhaas, T.H. Witney, D. Soloviev, K.J. Williams, A.H. Jacobs, E.O. Aboagye, J.R. Griffiths, K.M. Brindle (2016). The relationship between endogenous thymidine concentrations and [18F]FLT uptake in a range of preclinical tumour models. EJNMMI Res 6:63.

S. Merchant*, L. Allott*, L.S. Carroll, V. Tittrea, S. Kealey, T.H. Witney, P. Miller, G. Smith and E. O. Aboagye (2016). Synthesis and pre-clinical evaluation of a [18F]fluoromethyl-Tanaproget derivative for imaging of progesterone receptor expression. RSC Adv 6, pp.57569-79.

E. Chang, C. Pohling, A. Natarajan, T.H. Witney, J. Kaur, L. Xu, G. Gowrishankar, A. de Souza, S. Murty, S. Schick, L. Chan, N. Wu, P. Khaw, P. Mischel, T. Abbasi, S. Usmani, P. Mallick, S. S. Gambhir (2016). AshwaMAX and Withaferin A inhibits gliomas in cellular and murine orthotopic models. J Neurooncol 126, pp.253-264.

T.H. Witney*, M.L. James*, B. Shen, E. Chang, C. Pohling, N. Arksey, A. Hoehne, A.J. Shuhendler, J-H. Park, D. Bodapati, J. Weber, J. Rao, F.T. Chin & S.S. Gambhir (2015). PET imaging of tumour glycolyosis downstream of hexokinase through noninvasive measurement of pyruvate kinase M2. Sci Transl Med 7, 310ra169. 

Click on the above link to view the article at Science Translational Medicine. For free access to the full text, please click here.

T.H. Witney*, A. Hoehne*, R.E. Reeves, O. Ilovich, M. Namavari, B. Shen, F.T. Chin, J. Rao & S.S Gambhir (2015). A systematic comparison of 18F-C-SNAT to established radiotracer imaging agents for the detection of tumor response to treatment. Clin Cancer Res 21, pp.3896-3905.

T.H. Witney, F. Pisaneschi, I.S. Alam, S. Trousil, M. Kaliszczak, F. Twyman, D. Brickute Q. Nguyen, E. Schug, E. Gottlieb & E. O. Aboagye (2014). Preclinical Evaluation of 18F-Fluoro-Pivalic Acid as a Novel Imaging Agent for Tumor Detection. J Nucl Med 55, pp.1506-1512.

I.S. Alam, T.H. Witney, G. Tomasi, L. Carroll, F. Twyman, Q.D. Nguyen & E.O. Aboagye (2014).  Radiolabeled RGD tracer kinetics annotates differential αvβ 3 integrin expression linked to cell intrinsic and vessel expression. Mol Imag Biol 16, pp.558-566.

S. Merchant, T.H. Witney & E.O. Aboagye (2014). Imaging as a pharmacodynamic and response biomarker in cancer. Clin Transl Imaging 2, pp.13-31.

T.H. Witney, R. Fortt & E.O. Aboagye (2014). Preclinical Assessment of Carboplatin Treatment Efficacy in Lung Cancer by 18F-ICMT-11-Positron Emission Tomography.  PLoS ONE 9(3), e.91694.

T.H. Witney, L. Carroll, I.S. Alam, A. Chandrashekran, Q.D. Nguyen, R. Sala, R. Harris, R. J. DeBerardinis, R. Argarwal & E.O. Aboagye (2014). A novel radiotracer to image glycogen metabolism in tumors by positron emission tomography. Cancer Res 47(5), pp.1319-1328.

F. Pisaneschi*, T.H. Witney*, L. Iddon* & E.O. Aboagye (2013). Synthesis of [18F]fluoro-pivalic acid: an improved PET imaging probe for the fatty acid synthesis pathway in tumours. Med Chem Commun 4, pp.1350-1353.

L. Carroll, T.H. Witney & E.O. Aboagye (2013). Design and synthesis of novel 18F-radiolabelled glucosamine derivatives for cancer imaging. Med Chem Commun 4, pp.653-656.

M.R. Clatworthy, M.I. Kettunen, D-E. Hu, R. Matthews, T.H. Witney, B.W.C. Kennedy, S.E. Bohndiek, F.A. Gallagher, L. Jarvis, K.G.C. Smith, K.M. Brindle (2012). Magnetic resonance imaging with hyperpolarized [1,4-13C2]fumarate allows detection of early renal acute tubular necrosis.  Proc Natl Acad Sci USA 109(33), pp.13374-13379.

T.H. Witney, I.A. Alam, D.R. Turton, G. Smith, L. Carroll, D. Brickute, F.J. Twyman, Q-D. Nguyen, G. Tomasi, R. Awais & E.O. Aboagye (2012). Evaluation of Deuterated 18F- and 11C-Labeled Choline Analogs for Cancer Detection by Positron Emission Tomography. Clin Cancer Res 18(4), pp.1063-1072.

T.H. Witney, M.I. Kettunen & K.M. Brindle (2011).  Kinetic modeling of hyperpolarized 13C label exchange between pyruvate and lactate in tumor cells. J Biol Chem 286, pp.24572-24580.

S.E. Bohndiek, M.I. Kettunen, D-E. Hu, T.H. Witney, B.W.C. Kennedy, F.A. Gallagher & K.M. Brindle (2010).  Detecting tumor response to a vascular disrupting agent by hyperpolarized 13C magnetic resonance spectroscopy.  Mol Cancer Ther 9(12), pp.3278-3288.

T.H. Witney, M.I. Kettunen, D-E. Hu, F.A. Gallagher & K.M. Brindle (2010).  Detecting response to treatment in a model of human breast adenocarcinoma using hyperpolarized [1-13C]pyruvate and [1,4-13C2]fumarate. Brit J Cancer 103, pp.1400-1406.

T.H. Witney & K.M Brindle (2010).  Imaging Tumour Cell Metabolism Using Hyperpolarised 13C Magnetic Resonance Spectroscopy. Biochem Soc Trans 38(5), pp.1220-1224.

I.A. Alam, A.A. Neves, T.H. Witney, J. Boren & K.M. Brindle (2010). Comparison of the C2A domain of Synaptotagmin-I and Annexin-V as probes for detecting cell death. Bioconjugate Chem 21, pp.884-891.

M.I. Kettunen, D-E. Hu, T.H Witney, R. McLaughlin, F.A. Gallagher, S.E Bohndiek & K.M. Brindle (2010).  Magnetization transfer measurements of exchange between hyperpolarized [1-13C]pyruvate and [1-13C]lactate in a murine lymphoma. Mag Res Med 63(4), pp.872-880.

F.A. Gallagher, M.I. Kettunen, D-E. Hu, P.R. Jensen, R. Zandt, M. Karlsson, A. Gisselsson, S.K. Nelson, T.H. Witney, S.E. Bohndiek, G. Hansson, T. Peitersen, M.H. Lerche & K.M. Brindle (2009).  Production of hyperpolarized [1,4-13C2]malate from [1,4-13C2]fumarate as a marker of cell necrosis and treatment response in tumors. Proc Natl Acad Sci USA 106(47), pp.19801-6.

T.H. Witney, M.I. Kettunen, S.E. Day, D-E. Hu, A.A. Neves, F.A. Gallagher, S.M Fulton, & K.M. Brindle (2009).  A comparison between measurements of radiolabeled fluorodeoxyglucose uptake and hyperpolarized 13C-labeled pyruvate utilization as methods for detecting tumor response to treatment.  Neoplasia 11, pp.574-582.

†Co-corresponding and senior authors

*Joint-first author